Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism

Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs. However, the effect of verapamil on the pharmacokinetics of HCPT was not...

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Main Authors: Hua Xing (Author), Xiao Luo (Author), Yang Li (Author), Chunni Fan (Author), Ning Liu (Author), Chunguo Cui (Author), Wenjia Li (Author)
Format: Book
Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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