Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism

• Main Authors: Hua Xing (Author), Xiao Luo (Author), Yang Li (Author), Chunni Fan (Author), Ning Liu (Author), Chunguo Cui (Author), Wenjia Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs. However, the effect of verapamil on the pharmacokinetics of HCPT was not...