Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism

• मुख्य लेखकों: Hua Xing (लेखक), Xiao Luo (लेखक), Yang Li (लेखक), Chunni Fan (लेखक), Ning Liu (लेखक), Chunguo Cui (लेखक), Wenjia Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs. However, the effect of verapamil on the pharmacokinetics of HCPT was not...