Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation

Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation

Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs). The aim of the present study was to evaluate the inhibitory effects of two b-glucuroni...

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Main Authors: Takashi Satoh (Author), Ayaka Igarashi (Author), Misaki Tanno (Author), Koki Yamada (Author), Natsuko Takahashi-Suzuki (Author), Kazuhiro Watanabe (Author)
Format: Book
Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
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3rd Floor Main Library

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