Population Pharmacokinetic Model of Piperacillin in Critically Ill Patients and Describing Interethnic Variation Using External Validation

• Main Authors: Cristina Sanches (Author), Geisa C. S. Alves (Author), Andras Farkas (Author), Samuel Dutra da Silva (Author), Whocely Victor de Castro (Author), Farah Maria Drummond Chequer (Author), Francisco Beraldi-Magalhães (Author), Igor Rafael dos Santos Magalhães (Author), André de Oliveira Baldoni (Author), Mark D. Chatfield (Author), Jeffrey Lipman (Author), Jason A. Roberts (Author), Suzanne L. Parker (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: This study aimed to develop a piperacillin population PK model for critically ill Brazil-ian patients and describe interethnic variation using an external validation. Methods: Plasma samples were obtained from 24 ICU patients during the fifth day of piperacillin treatment and assayed by...