In silico and in vivo evaluations of fisetin and fisetin-loaded nanosuspension on monoamine oxidase inhibition in Aβ(25-35) induced dementia in mice model

• Main Authors: Siti Zaidathul Iman Zolkiffly (Author), Mizaton Hazizul Hasan (Author), Siti Azma Jusoh (Author), Ashok Kumar Janakiraman (Author), Sathesh Kumar Sukumaran (Author), Noreen Husain (Author), Yuslina Zakaria (Author), Hanish Singh Jayasingh Chellammal (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Amyloid beta (Aβ) plaques on the extracellular matrix and intracellular neurofibrillary tangles comprise the key indicative pathology of Alzheimer's disease (AD). Fisetin, an antioxidant bioactive compound having pharmacotherapeutic effects is applied by traditional Chinese medicine...