The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

• Main Authors: Elvira Bailón (Author), Juan Román (Author), Isabel Ramis (Author), Pedro Michelena (Author), Dolors Balsa (Author), Manuel Merlos (Author), Antonio Zarzuelo (Author), Julio Gálvez (Author), Mònica Comalada (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 μM) inhibited both the production of int...