sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis.

• Main Authors: Ricardo Luís Louzada Silva (Author), Marcio B Santos (Author), Priscila L S Almeida (Author), Thayse S Barros (Author), Lucas Magalhães (Author), Rodrigo A Cazzaniga (Author), Patrícia R M Souza (Author), Nívea F Luz (Author), Jaqueline França-Costa (Author), Valeria M Borges (Author), Djalma S Lima-Junior (Author), Michael W Lipscomb (Author), Malcolm S Duthie (Author), Steven G Reed (Author), Roque Pacheco Almeida (Author), Amélia Ribeiro Jesus (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:CD163, receptor for the haptoglobin-hemoglobin complex, is expressed on monocytes/macrophages and neutrophils. A soluble form of CD163 (sCD163) has been associated with the M2 macrophage phenotype, and M2 macrophages have been shown to down-modulate inflammatory responses. In particular,...