Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1

• Үндсэн зохиолчид: Sonam Roy (Зохиогч), Amarjyoti Das Mahapatra (Зохиогч), Taj Mohammad (Зохиогч), Preeti Gupta (Зохиогч), Mohamed F. Alajmi (Зохиогч), Afzal Hussain (Зохиогч), Md. Tabish Rehman (Зохиогч), Bhaskar Datta (Зохиогч), Md. Imtaiyaz Hassan (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2020-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first-generation inhibitors are great challenge. In sear...