Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB

• Main Authors: Jeanne Durendale Chiadak (Author), Tatjana Arsenijevic (Author), Kevin Verstrepen (Author), Françoise Gregoire (Author), Nargis Bolaky (Author), Valérie Delforge (Author), Véronique Flamand (Author), Jason Perret (Author), Christine Delporte (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In an obese state, Toll-like receptor-4 (TLR-4) upregulates proinflammatory adipokines secretion including monocyte chemotactic protein-1 (MCP-1) in adipose tissue. In contrast, G-protein coupled receptor 120 (GPR120) mediates antiobesity effects. The aim of this study was to determine the signaling...