Raynaud's Phenomenon: a Brief Review of the Underlying Mechanisms

• Main Authors: Manal Fardoun (Author), Joseph Nassif (Author), Khodr Issa (Author), Elias Baydoun (Author), Ali Hussein Eid (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Raynaud's phenomenon (RP) is characterized by exaggerated cold-induced vasoconstriction. This augmented vasoconstriction occurs by virtue of a reflex response to cooling via the sympathetic nervous system as well as by local activation of α2C adrenoceptors (α2C-AR). In a cold-initiated, mitocho...