Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus.

• Main Authors: Yi-Ping Kuo (Author), Kuen-Nan Tsai (Author), Yin-Chiu Luo (Author), Pei-Jung Chung (Author), Yu-Wen Su (Author), Yu Teng (Author), Ming-Sian Wu (Author), Yu-Feng Lin (Author), Chao-Yang Lai (Author), Tsung-Hsien Chuang (Author), Shih-Syong Dai (Author), Fan-Chen Tseng (Author), Cheng-Han Hsieh (Author), De-Jiun Tsai (Author), Wan-Ting Tsai (Author), Chun-Hong Chen (Author), Guann-Yi Yu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zika virus (ZIKV) is primarily transmitted by Aedes mosquitoes in the subgenus Stegomyia but can also be transmitted sexually and vertically in humans. STAT1 is an important downstream factor that mediates type I and II interferon signaling. In the current study, we showed that mice with STAT1 knock...