The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles

New 7-amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives, substituted at the 5-position with aryl(alkyl)amino- and 4-substituted-piperazin-1-yl- moieties, were synthesized with the aim of targeting human (h) adenosine A1 and/or A2A receptor subtypes. On the whole, the novel derivatives 1-24 shared...

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Main Authors: Lucia Squarcialupi (Author), Marco Betti (Author), Daniela Catarzi (Author), Flavia Varano (Author), Matteo Falsini (Author), Annalisa Ravani (Author), Silvia Pasquini (Author), Fabrizio Vincenzi (Author), Veronica Salmaso (Author), Mattia Sturlese (Author), Katia Varani (Author), Stefano Moro (Author), Vittoria Colotta (Author)
Format: Book
Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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