Discovery of Nitro-azolo[1,5-<i>a</i>]pyrimidines with Anti-Inflammatory and Protective Activity against LPS-Induced Acute Lung Injury

• Main Authors: Alexander Spasov (Author), Vadim Kosolapov (Author), Denis Babkov (Author), Vladlen Klochkov (Author), Elena Sokolova (Author), Mikhail Miroshnikov (Author), Alexander Borisov (Author), Yulia Velikorodnaya (Author), Alexey Smirnov (Author), Konstantin Savateev (Author), Victor Fedotov (Author), Svetlana Kotovskaya (Author), Vladimir Rusinov (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lung injury remains a challenging clinical condition, necessitating the development of novel, safe and efficient treatments. The prevention of macrophage M1-polarization is a viable venue to tackle excessive inflammation. We performed a phenotypic screening campaign to identify azolopyrimidine...