The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species

• Main Authors: Luigi Di Luigi (Author), Guglielmo Duranti (Author), Ambra Antonioni (Author), Paolo Sgrò (Author), Roberta Ceci (Author), Clara Crescioli (Author), Stefania Sabatini (Author), Andrea Lenzi (Author), Daniela Caporossi (Author), Francesco Del Galdo (Author), Ivan Dimauro (Author), Cristina Antinozzi (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Systemic sclerosis (SSc) is a multi-system connective tissue disease characterized by the increased deposition of extracellular matrix proteins such as collagen and fibronectin. Although the pathogenesis is not completely understood, a number of studies suggest that free radicals could be the major...