The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species

• Автори: Luigi Di Luigi (Автор), Guglielmo Duranti (Автор), Ambra Antonioni (Автор), Paolo Sgrò (Автор), Roberta Ceci (Автор), Clara Crescioli (Автор), Stefania Sabatini (Автор), Andrea Lenzi (Автор), Daniela Caporossi (Автор), Francesco Del Galdo (Автор), Ivan Dimauro (Автор), Cristina Antinozzi (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Systemic sclerosis (SSc) is a multi-system connective tissue disease characterized by the increased deposition of extracellular matrix proteins such as collagen and fibronectin. Although the pathogenesis is not completely understood, a number of studies suggest that free radicals could be the major...