α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis

• Main Authors: Tian-Tian Jiang (Author), Chao-Fan Ji (Author), Xiu-Ping Cheng (Author), Shao-Fei Gu (Author), Rui Wang (Author), Yan Li (Author), Jian Zuo (Author), Jun Han (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A previously validated anti-rheumatic compound α-mangostin (MAN) shows significant metabolism regulatory effects. The current study aimed to clarify whether this property contributed to its inhibition on synovial angiogenesis. Male wistar rats with adjuvant-induced arthritis (AIA) were orally treate...