Sex Differences in Intestinal P-Glycoprotein Expression in Wistar versus Sprague Dawley Rats

• Main Authors: Christine M. Madla (Author), Yujia Qin (Author), Francesca K. H. Gavins (Author), Jing Liu (Author), Liu Dou (Author), Mine Orlu (Author), Sudaxshina Murdan (Author), Yang Mai (Author), Abdul W. Basit (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wistar and Sprague Dawley are the most common strains of rat used in pharmaceutical research and are used interchangeably in pre-clinical drug development. No studies have assessed whether Wistar and Sprague Dawley rats are equivalent in the gastrointestinal factors that influence oral drug absorpti...