Evaluation of limited-sampling strategies to calculate AUC(0-24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

Evaluation of limited-sampling strategies to calculate AUC(0-24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

Background: Kidney transplantation (KTx) requires immunosuppressive drugs such as Tacrolimus (TAC) which is mainly metabolized by CYP3A5. TAC is routinely monitored by trough levels (C0) although it has not shown to be a reliable marker. The area-under-curve (AUC) is a more realistic measure of drug...

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Main Authors: Carla Galvez (Author), Pía Boza (Author), Mariluz González (Author), Catalina Hormazabal (Author), Marlene Encina (Author), Manuel Azócar (Author), Luis E. Castañeda (Author), Angélica Rojo (Author), María Luisa Ceballos (Author), Paola Krall (Author)
Format: Book
Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
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