Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches

• Main Authors: David Hoffmann (Author), Joschka Bauer (Author), Markus Kossner (Author), Andrew Henry (Author), Anne R. Karow-Zwick (Author), Giuseppe Licari (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAsparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection...