Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches
ABSTRACTAsparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection...
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Taylor & Francis Group,
2024-12-01T00:00:00Z.
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