Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches

• Үндсэн зохиолчид: David Hoffmann (Зохиогч), Joschka Bauer (Зохиогч), Markus Kossner (Зохиогч), Andrew Henry (Зохиогч), Anne R. Karow-Zwick (Зохиогч), Giuseppe Licari (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

ABSTRACTAsparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection...