Influence of Novel Supramolecular Substance, [2] Rotaxane, on the Caspase Signaling Pathway in Melanoma and Colon Cancer Cells In Vitro

Influence of Novel Supramolecular Substance, [2] Rotaxane, on the Caspase Signaling Pathway in Melanoma and Colon Cancer Cells In Vitro

We studied the influence of novel supramolecular substance, [2] rotaxane (TRO-A0001), on caspase signaling and cell viability in cancer cell lines. TRO-A0001 suppressed concentration-dependently cell proliferation. Expression of the cleaved-form caspase-3 and PARP was significantly increased in cell...

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Main Authors: Kazuki Hara (Author), Tatsuya Beppu (Author), Masahiko Kimura (Author), Yoshihiko Fujita (Author), Toshikazu Takata (Author), Kazuto Nishio (Author), Nobufumi Ono (Author)
Format: Book
Published: Elsevier, 2013-01-01T00:00:00Z.
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