Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

• Main Authors: José Javier López-Cano (Author), Sigen A. (Author), Vanessa Andrés-Guerrero (Author), Hongyun Tai (Author), Irene Bravo-Osuna (Author), Irene Teresa Molina-Martínez (Author), Wenxin Wang (Author), Rocío Herrero-Vanrell (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aims to develop a thermo-responsive-injectable hydrogel (HyG) based on PLGA-PEG-PLGA (PLGA = poly-(DL-lactic acid co-glycolic acid); PEG = polyethylene glycol) to deliver neuroprotective agents to the retina over time. Two PLGA-PEG PLGA copolymers with different PEG:LA:GA ratios (1...