Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic application

• Main Authors: Demétrius Fernandes do Nascimento (Author), Manoel Odorico de Moraes (Author), Fernando Antônio Frota Bezerra (Author), Andréa Vieira Pontes (Author), Célia Regina Amaral Uchoa (Author), Renata Amaral de Moraes (Author), Ismenia Osório Leite (Author), Gilmara Silva de Melo Santana (Author), Ana Paula Macedo Santana (Author), Ana Lourdes Almeida e Silva Leite (Author), José Pedrazzoli Júnior (Author), Maria Elisabete Amaral de Moraes (Author)
• Format: Book
• Published: Universidade de São Paulo, 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic sepa...