Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells

• Main Authors: Jie Chen (Author), Long Zhao (Author), Meng-Fan Xu (Author), Di Huang (Author), Xiao-Long Sun (Author), Yu-Xin Zhang (Author), Hong-Mei Li (Author), Cheng-Zhu Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractIn this study, seventeen isobavachalcone (IBC) derivatives (1-17) were synthesised, and evaluated for their cytotoxic activity against three human lung cancer cell lines. Among these derivatives, compound 16 displayed the most potent cytotoxic activity against H1975 and A549 cells, with IC50...