Bazedoxifene Regulates Th17 Immune Response to Ameliorate Experimental Autoimmune myocarditis via Inhibition of STAT3 Activation

• Main Authors: Jing Wang (Author), Tianshu Liu (Author), Xiongwen Chen (Author), Qiaofeng Jin (Author), Yihan Chen (Author), Li Zhang (Author), Zhengyang Han (Author), Dandan Chen (Author), Yuman Li (Author), Qing Lv (Author), Mingxing Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myocarditis is a type of inflammatory cardiomyopathy that has no specific treatment. Accumulating evidence suggests that Th17 cells play a prominent role in the pathogenesis of myocarditis. Interleukin-(IL)-6-mediated signal transducer and activation of transcription 3 (STAT3) signaling is essential...