Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

• Main Authors: Tim S. Ellison (Author), Samuel J. Atkinson (Author), Veronica Steri (Author), Benjamin M. Kirkup (Author), Michael E. J. Preedy (Author), Robert T. Johnson (Author), Christiana Ruhrberg (Author), Dylan R. Edwards (Author), Jochen G. Schneider (Author), Katherine Weilbaecher (Author), Stephen D. Robinson (Author)
• Format: Book
• Published: The Company of Biologists, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation o...