CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

• Main Authors: Dafné Moreno Lorenzana (Author), María del Rocío Juárez Velázquez (Author), Adriana Reyes León (Author), Daniel Martínez Anaya (Author), Adrián Hernández Monterde (Author), Consuelo Salas Labadía (Author), María del Pilar Navarrete Meneses (Author), Marta Zapata Tarrés (Author), Luis Juárez Villegas (Author), Berenice Jarquín Ramírez (Author), Rocío Cárdenas Cardós (Author), Martha Herrera Almanza (Author), Rogelio Paredes Aguilera (Author), Patricia Pérez Vera (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The gene fusions BCR‐ABL1, TCF3‐PBX1, and ETV6‐RUNX1 are recurrent in B‐cell acute lymphoblastic leukemia (B‐ALL) and are found with low frequency in coexistence with CRLF2 (cytokine receptor‐like factor 2) rearrangements and overexpression. There is limited information regarding the CRLF2...