Surface engineered mesoporous silica carriers for the controlled delivery of anticancer drug 5-fluorouracil: Computational approach for the drug-carrier interactions using density functional theory

• Main Authors: Fozia Rehman (Author), Asif Jamal Khan (Author), Zaib Us Sama (Author), Hussah M. Alobaid (Author), Mazhar Amjad Gilani (Author), Sher Zaman Safi (Author), Nawshad Muhammad (Author), Abdur Rahim (Author), Abid Ali (Author), Jiahua Guo (Author), Muhammad Arshad (Author), Talha Bin Emran (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Drug delivery systems are the topmost priority to increase drug safety and efficacy. In this study, hybrid porous silicates SBA-15 and its derivatives SBA@N and SBA@3N were synthesized and loaded with an anticancer drug, 5-fluorouracil. The drug release was studied in a simulated physi...