Identification of mIDH1 R132C/S280F Inhibitors from Natural Products by Integrated Molecular Docking, Pharmacophore Modeling and Molecular Dynamics Simulations

• প্রধান লেখক: Weitong Zhang (লেখক), Hailong Bai (লেখক), Yifan Wang (লেখক), Xiaorui Wang (লেখক), Ruyi Jin (লেখক), Hui Guo (লেখক), Huanling Lai (লেখক), Yuping Tang (লেখক), Yuwei Wang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Mutant isocitrate dehydrogenase 1 (mIDH1) is a common driving factor in acute myeloid leukemia (AML), with the R132 mutation accounting for a high proportion. The U.S. Food and Drug Administration (FDA) approved Ivosidenib, a molecular entity that targets IDH1 with R132 mutations, as a promising the...