Identification of Triazolopyrimidinyl Scaffold SARS-CoV-2 Papain-Like Protease (PL^pro) Inhibitor

• Main Authors: Sebastjan Kralj (Author), Marko Jukič (Author), Miha Bahun (Author), Luka Kranjc (Author), Anja Kolarič (Author), Milan Hodošček (Author), Nataša Poklar Ulrih (Author), Urban Bren (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its companion disease, COVID-19, has reminded us of the importance of basic coronaviral research. In this study, a comprehensive approach using molecular docking, in vitro assays, and molecular dynamics simulations...