Co-delivery of docetaxel and bortezomib based on a targeting nanoplatform for enhancing cancer chemotherapy effects

• Main Authors: Junpeng Nie (Author), Wei Cheng (Author), Yunmei Peng (Author), Gan Liu (Author), Yuhan Chen (Author), Xusheng Wang (Author), Chaoyu Liang (Author), Wei Tao (Author), Yinping Wei (Author), Xiaowei Zeng (Author), Lin Mei (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using facile polydopamine (PDA)-based surface modification and a pH-sensitive catechol-boronate binding mechanism, a novel drug delivery system was designed for the treatment of breast cancer. The system was able to achieve the following goals: active targeting, pH responsiveness, in vivo blood circ...