Cellular Imaging: a Key Phenotypic Screening Strategy for Predictive Toxicology
Incorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus pro...
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| Format: | Book |
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Frontiers Media S.A.,
2015-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Incorporating phenotypic screening as a key strategy will enhances confidence in the predictivity and translatability of drug discovery efforts. Cellular imaging serves as the a phenotypic anchor to identify important toxicologic pathology that encompasses an array of underlying mechanisms, thus provides an effective means to reduce drug development failures due to insufficient safety. This mini-review highlights the latest advances in hepatotoxicity, cardiotoxicity, and genetic toxicity tests that utilized cellular imaging as a screening strategy, and recommends path forward for further improvement. |
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| Item Description: | 1663-9812 10.3389/fphar.2015.00191 |