Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity

• Main Authors: Si Huang (Author), Jingxian Xiao (Author), Junyong Wu (Author), Jiayi Liu (Author), Xueping Feng (Author), Chengdong Yang (Author), Daxiong Xiang (Author), Shilin Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The antiparasitic drug nitazoxanide (NTZ) has received considerable attention for its potential in cancer therapy. In this study, we demonstrate that tizoxanide (TIZ), an active metabolite of NTZ, exhibits antiglioma activity in vitro and in vivo by inducing G2/M cell cycle arrest and apoptosis. In...