Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy

• Autori principali: Maria Bernadete Riemma Pierre (Autore), Renata Fonseca Vianna Lopez (Autore), Maria Vitória Lopes Badra Bentley (Autore)
• Natura: Libro
• Pubblicazione: Universidade de São Paulo, 2009-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Photodynamic therapy (PDT) based on topical 5-aminolevulinic acid (5-ALA), an endogenous precursor of protoporphyrin, is an interesting approach for the treatment of skin cancer. However, 5-ALA is a hydrophilic molecule and such a characteristic limits its appropriate cutaneous penetration and reten...