Investigation of a Potential Pharmacokinetic Interaction Between Nebivolol and Fluvoxamine in Healthy Volunteers

• Main Authors: Ana-Maria Gheldiu (Author), Laurian Vlase (Author), Adina Popa (Author), Corina Briciu (Author), Dana Muntean (Author), Corina Bocsan (Author), Anca Buzoianu (Author), Marcela Achim (Author), Ioan Tomuta (Author), Ioana Todor (Author), Maria Neag (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: To investigate whether fluvoxamine coadministration can influence the pharmacokinetic properties of nebivolol and its active hydroxylated metabolite (4-OH-nebivolol) and to assess the consequences of this potential pharmacokinetic interaction upon nebivolol pharmacodynamics. Methods: This o...