β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders

• Main Authors: Jaana van Gastel (Author), Jhana O. Hendrickx (Author), Hanne Leysen (Author), Paula Santos-Otte (Author), Louis M. Luttrell (Author), Bronwen Martin (Author), Stuart Maudsley (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein coupled receptors (GPCRs) were first characterized as signal transducers that elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins. The pharmacotherapeutic exploitation of this signaling paradigm has created a drug-based field covering nearly 50% of the c...