Inhibition of microRNA-494-3p activates Wntsignaling and reduces proinflammatorymacrophage polarization in atherosclerosis

• Main Authors: Eva van Ingen (Author), Amanda C. Foks (Author), Tamar Woudenberg (Author), M. Leontien van der Bent (Author), Alwin de Jong (Author), Philipp J. Hohensinner (Author), Johann Wojta (Author), Ilze Bot (Author), Paul.H.A. Quax (Author), Anne Yaël Nossent (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown that treatment with third-generation antisense oligonucleotides against miR-494-3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage content in established plaques. Within the plaque, d...