Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions

• Main Authors: Ryoma Morigaki (Author), Jannifer H. Lee (Author), Tomoko Yoshida (Author), Christian Wüthrich (Author), Dan Hu (Author), Jill R. Crittenden (Author), Alexander Friedman (Author), Yasuo Kubota (Author), Ann M. Graybiel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The striatum of humans and other mammals is divided into macroscopic compartments made up of a labyrinthine striosome compartment embedded in a much larger surrounding matrix compartment. Anatomical and snRNA-Seq studies of the Huntington's disease (HD) postmortem striatum suggest a preferentia...