Evaluating and Improving Neonatal Gentamicin Pharmacokinetic Models Using Aggregated Routine Clinical Care Data

• Hoofdauteurs: Dominic M. H. Tong (Auteur), Jasmine H. Hughes (Auteur), Ron J. Keizer (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Model-informed precision dosing (MIPD) can aid dose decision-making for drugs such as gentamicin that have high inter-individual variability, a narrow therapeutic window, and a high risk of exposure-related adverse events. However, MIPD in neonates is challenging due to their dynamic development and...