Grandisin induces apoptosis in leukemic K562 cells

• Main Authors: Alane Pereira Cortez (Author), Elizabeth Gomes Paulino Menezes (Author), Polyana Lopes Benfica (Author), Alexandre Pereira dos Santos (Author), Larissa Moreira Cleres (Author), Higor de Oliveira Ribeiro (Author), Eliana Martins Lima (Author), Massuo Jorge Kato (Author), Marize Campos Valadares (Author)
• Format: Book
• Published: Universidade de São Paulo, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against the leukemic line K562. The cytotoxicity of grandisin (0.018 to 2.365 µM) was evaluated in K562 and normal peripheral blood lymphocytes by Trypan Blue Exclusion a...