Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

• Главные авторы: Seo-Young Park (Автор), Susan Egan (Автор), Anthony J. Cura (Автор), Kathryn L. Aron (Автор), Xuankuo Xu (Автор), Mengyuan Zheng (Автор), Michael Borys (Автор), Sanchayita Ghose (Автор), Zhengjian Li (Автор), Kyongbum Lee (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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Monoclonal antibody (mAb) interchain disulfide bond reduction can cause a loss of function and negatively impact the therapeutic's efficacy and safety. Disulfide bond reduction has been observed at various stages during the manufacturing process, including processing of the harvested material....