Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

• Main Authors: Chiung-Kuang Chen (Author), Siegfried S F Leung (Author), Christophe Guilbert (Author), Matthew P Jacobson (Author), James H McKerrow (Author), Larissa M Podust (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas Disease is the leading cause of heart failure in Latin America. Current drug therapy is limited by issues of both efficacy and severe side effects. Trypansoma cruzi, the protozoan agent of Chagas Disease, is closely related to two other major global pathogens, Leishmania spp., responsible for...