Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

• Main Authors: Xinyun Jian (Author), Cheng Wang (Author), Shijuan Wu (Author), Guo Sun (Author), Chuan Huang (Author), Chengbing Qiu (Author), Yuanzheng Liu (Author), Peter F. Leadlay (Author), Dong Liu (Author), Zixin Deng (Author), Fuling Zhou (Author), Yuhui Sun (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aminoglycosides (AGs) are a class of antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance. To address these issues, semi-synthetic approaches for modifying natural AGs have generated...