Study on the Characteristics of Small-Molecule Kinase Inhibitors-Related Drug-Induced Liver Injury

• Main Authors: Huiqun Dong (Author), Jia You (Author), Yu Zhao (Author), Danhua Zheng (Author), Yi Zhong (Author), Gaozheng Li (Author), Zuquan Weng (Author), Heng Luo (Author), Shan Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aim: More than half of the small-molecule kinase inhibitors (KIs) induced liver injury clinically. Meanwhile, studies have shown a close relationship between mitochondrial damage and drug-induced liver injury (DILI). We aimed to study KIs and the binding between drugs and mitochondria...