HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance

• Main Authors: Bin Shi (Author), Fang-Fang Xu (Author), Cai-Ping Xiang (Author), Chuan-Yan Li (Author), Ping Fan (Author), Hao Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

5-Fluorouracil (5-Fu) is one of the basic drugs in colorectal cancer (CRC) chemotherapy, and its efficacy is mainly limited by the acquisition of drug resistance. However, the underlying mechanisms remain unclear. In this study, hypoxia inducible factor 1α (HIF1α) was screened for high expression in...