HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance

• Egile Nagusiak: Bin Shi (Egilea), Fang-Fang Xu (Egilea), Cai-Ping Xiang (Egilea), Chuan-Yan Li (Egilea), Ping Fan (Egilea), Hao Wang (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

5-Fluorouracil (5-Fu) is one of the basic drugs in colorectal cancer (CRC) chemotherapy, and its efficacy is mainly limited by the acquisition of drug resistance. However, the underlying mechanisms remain unclear. In this study, hypoxia inducible factor 1α (HIF1α) was screened for high expression in...