Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl-deoxynojirimycin derivatives as potential α-glucosidase inhibitors

• Main Authors: Ping Lin (Author), Jia-Cheng Zeng (Author), Ji-Guang Chen (Author), Xu-Liang Nie (Author), En Yuan (Author), Xiao-Qiang Wang (Author), Da-Yong Peng (Author), Zhong-Ping Yin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ∼ 44 were synthesised and evaluated for their in vitro α-glucosidase inhibitory activity to develop α-glucosidase inhibitors with high activity. All twenty compounds exhibited α-glucosidase inhibitory activity with IC50 values ranging from...