Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors

• Main Authors: Xiaorui Han (Author), Pingping Lan (Author), Qianfeng Chen (Author), Hua Liu (Author), Zhongwen Chen (Author), Tiantian Wang (Author), Zengtao Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibiting apoptosis signal regulated kinase 1 (ASK1) is an attractive strategy for treating diseases such as non-alcoholic steatohepatitis and multiple sclerosis. Here, we report the discovery of a dibromo substituted quinoxaline fragment containing 26e as an effective small-molecule inhibitor of A...