Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders

• Main Authors: Mikhail Ponomarenko (Author), Ekaterina Sharypova (Author), Irina Drachkova (Author), Irina Chadaeva (Author), Olga Arkova (Author), Olga Podkolodnaya (Author), Petr Ponomarenko (Author), Nikolay Kolchanov (Author), Ludmila Savinkova (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hemoglobin is a tetramer consisting of two α-chains and two β-chains of globin. Hereditary aberrations in the synthesis of one of the globin chains are at the root of thalassemia, one of the most prevalent monogenic diseases worldwide. In humans, in addition to α- and β-globins,...