Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia

• Main Authors: Alessandro Falsini (Author), Gaia Giuntini (Author), Mattia Mori (Author), Francesca Ghirga (Author), Deborah Quaglio (Author), Antonino Cucinotta (Author), Federica Coppola (Author), Irene Filippi (Author), Antonella Naldini (Author), Bruno Botta (Author), Fabio Carraro (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanoma is the principal cause of death in skin cancer due to its ability to invade and cause metastasis. Hypoxia, which characterises the tumour microenvironment (TME), plays an important role in melanoma development, as cancer cells can adapt and acquire a more aggressive phenotype. Carbonic anhy...