Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.

• Main Authors: Saskia Decuypere (Author), Manu Vanaerschot (Author), Kirstyn Brunker (Author), Hideo Imamura (Author), Sylke Müller (Author), Basudha Khanal (Author), Suman Rijal (Author), Jean-Claude Dujardin (Author), Graham H Coombs (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is universal for the studied pathogen; it has seldom bee...