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Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies

Novel 5-deazaflavins were designed as potential anticancer candidates. Compounds 4j, 4k, 5b, 5i, and 9f demonstrated high cytotoxicity against MCF-7 cell line with IC50 of 0.5-190nM. Compounds 8c and 9g showed preferential activity against Hela cells (IC50: 1.69 and 1.52 μM respectively). However, c...

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Main Authors:	Walaa A. Bedewy (Author), Mosaad S. Mohamed (Author), Ahmed M. Abdelhameed (Author), Mohamed A. Elsawy (Author), Mohammed Al-Muhur (Author), Noriyuki Ashida (Author), Ashraf N Abdalla (Author), Tamer A. Elwaie (Author), Tomohisa Nagamatsu (Author), Hamed I. Ali (Author)
Format:	Book
Published:	Taylor & Francis Group, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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