Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells

• Main Authors: Tzu-Jung Yu (Author), Jun-Ping Shiau (Author), Jen-Yang Tang (Author), Chia-Hung Yen (Author), Ming-Feng Hou (Author), Yuan-Bin Cheng (Author), Chih-Wen Shu (Author), Hsueh-Wei Chang (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Physalis peruviana</i>-derived physapruin A (PHA) is a potent compound that selectively generates reactive oxygen species (ROS) and induces cancer cell death. Autophagy, a cellular self-clearance pathway, can be induced by ROS and plays a dual role in cancer cell death. However, the r...