∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem‐like cells in human ER+ and HER2+ breast cancers

• Main Authors: Yajing Liu (Author), Marta Nekulova (Author), Rudolf Nenutil (Author), Iva Horakova (Author), M Virginia Appleyard (Author), Karen Murray (Author), Jitka Holcakova (Author), Michaela Galoczova (Author), Philip Quinlan (Author), Lee B Jordan (Author), Colin A Purdie (Author), Borivoj Vojtesek (Author), Alastair M Thompson (Author), Philip J Coates (Author)
• Format: Book
• Published: Wiley, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract ΔNp63, also known as p40, regulates stemness of normal mammary gland epithelium and provides stem cell characteristics in basal and HER2‐driven murine breast cancer models. Whilst ΔNp63/p40 is a characteristic feature of normal basal cells and basal‐type triple‐negative breast cancer, some...